Human yolk sac-like haematopoiesis generates RUNX1- and GFI1/1B-dependent blood and SOX17-positive endothelium
نویسندگان
چکیده
منابع مشابه
Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells.
We have previously shown that coculture of human embryonic stem cells (hESCs) for 14 days with immortalized fetal hepatocytes yields CD34(+) cells that can be expanded in serum-free liquid culture into large numbers of megaloblastic nucleated erythroblasts resembling yolk sac-derived cells. We show here that these primitive erythroblasts undergo a switch in hemoglobin (Hb) composition during la...
متن کاملInterplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac.
Endothelial to hematopoietic transition (EHT) is a dynamic process involving the shutting down of endothelial gene expression and switching on of hematopoietic gene transcription. Although the factors regulating EHT in hemogenic endothelium (HE) of the dorsal aorta have been relatively well studied, the molecular regulation of yolk sac HE remains poorly understood. Here, we show that SOX7 inhib...
متن کاملYOLK SAC TUMOR OF VAGINA
Malignant germ-cell tumors (MGCT) are rare tumors of childhood accounting for less than 3% of pediatric malignancies. Endodermal sinus tumor (EST) forms the most common histologic subtype of MGCT. The vagina is an extremely rare site for GCTs. An 8-month-old female was admitted with a short history of vaginal bleeding, and a mass protruding from the vagina. She was pale and a mass was palpab...
متن کاملSurface morphology of the human yolk sac: endoderm and mesothelium.
The yolk sac of human embryos from the 5th to 7th week of gestation was first revealed under the scanning electron microscope (SEM) with complementary observations under the transmission electron microscope (TEM). The inner and outer surfaces of the human yolk sac basically showed profiles similar to those of other mammalian yolk sacs reported by previous workers. The free surface of the endode...
متن کاملNovel, high-yield red blood cell production methods from CD34-positive cells derived from human embryonic stem, yolk sac, fetal liver, cord blood, and peripheral blood.
The current supply of red blood cells expressing rare blood groups is not sufficient to cover all the existing transfusion needs for chronically transfused patients, such as sickle cell disease homozygous carriers, because of alloimmunization. In vitro production of cultured red blood cells is slowly emerging as a possible complement to the existing collection-based red blood cell procurement s...
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ژورنال
عنوان ژورنال: Development
سال: 2020
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.193037